Cardiology

Safety and Efficacy of Extracorporeal Shock Wave Myocardial Revascularization Therapy for Refractory Angina Pectoris

Andrew Cassar, MD,MRCP; Megha Prasad, MD; Martin Rodriguez-Porcel,MD, FAHA; Guy S. Reeder, MD, FACC; Darshak Karia, MD; Anthony N. DeMaria, MD, MACC; and Amir Lerman, MD, FACC Mayo Clinic Proceedings, Volume 89, Issue 3, Pages 346–354, March 2014 Objective: To assess the safety and efficacy of extracorporeal shockwave myocardial revascularization (ESMR) therapy in treating patients with refractory angina pectoris. Patients and Methods: A single-arm multicenter prospective trial to assess safety and efficacy of the ESMR therapy in patients...

read more

Noninvasive Therapy for the Management of Patients With Advanced Coronary Artery Disease

By Kazmi W.H., Rasheed S.Z., Ahmed S., Saadat M., Altaf S., Samad A. (Coronary Artery Disease Journal, December 2012, Volume 23, Issue 8, P. 549-554) OBJECTIVES: To determine the efficacy of cardiac shock wave therapy (CSWT) in the management of patients with end-stage coronary artery disease (CAD). INTRODUCTION: Patients with end-stage CAD have symptoms such as recurrent angina, breathlessness, and other debilitating conditions. End-stage CAD patients are usually those who have angina pectoris following a coronary artery bypass surgery or a...

read more

The Efficacy of Cardiac Shock Wave Therapy in the Treatment of Refractory Angina: A Pilot Prospective, Randomized, Double-Blind Trial

David Leibowitz, A. Teddy Weiss, David Rott, Ronen Durst, Chaim Lotan (Int J Cardiol. 2012 Nov 30. doi:pii: S0167-5273(12)01582-3. 10.1016/j.ijcard.2012.11.099) Objective: This prospective, double-blind study was performed to evaluate the efficacy of low-energy extracorporeal shock wave therapy (ESWT) therapy in patients with refractory angina (RA). Background: Medical therapy for RA is limited and prognosis is poor. Experimental data suggest that the use of ESWT can contribute to angiogenesis and improve symptoms of angina. Methods: Patients...

read more

ESMR: Methodological Aspects and Preliminary Experience at Vilnius University Hospital

Objectives: To study the safety and effect of serial extracorporeal shockwave myocardial revascularization (ESMR) on patients’ symptoms and parameters of left ventricular function. Methods and results: the study group consisted of 16 patients (pts) with end-stage coronary artery disease (CAD), mostly after revascularization, in whom angina pectoris (AP) persisted despite optimal medical therapy. Prospective analysis data were collected from 16 pts (3 women, 13 men) with end-stage CAD (3-vessel disease) and AP CCS III-IV, 15/16 pts were after...

read more

Initial Clinical Experience With Extracorporeal Shock Wave Therapy in Treatment of Ischemic Heart Failure

Yury A. Vasyuk MD, Alla B. Hadzegova MD, Evgeny L. Shkolnik MD, Maya V. Kopeleva MD, Olga V. Krikunova MD, Elena N. Iouchtchouk MD, Elena M. Aronova MD, Svetlana V. Ivanova MD Previous experimental studies have suggested a beneficial effect of extracorporeal shock wave therapy (ESWT) in patients with ischemic heart failure. Twenty-four patients with ischemic heart failure and left ventricular ejection fraction (LVEF) <40% received ESWT in addition to their stable treatment. ESWT was performed in 9 sessions with 100 shocks per spot in...

read more

Extracorporeal Shock Wave Therapy Reverses Ischemia-Related Left Ventricular Dysfunction and Remodeling: Molecular-Cellular and Functional Assessment

By Fu M, Sun C-K, Lin Y-C, Wang C-J, Wu C-J, et al. (2011) An optimal treatment for patients with diffuse obstructive arterial disease unsuitable for catheter-based or surgical intervention is still pending. This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy may be a therapeutic alternative under such clinical situation. Myocardial ischemia was induced in male mini-pigs through applying an ameroid constrictor over mid-left anterior descending artery (LAD). Twelve mini-pigs were equally randomized into group 1...

read more

ESMR improves clinical symptoms and left ventricular function in patients with refractory angina

Zuozienė G, Laucevičius A, Leibowitz D. Vilnius University Clinic of Cardiovascular Diseases, Vilnius, Lithuania.   BACKGROUND: Medical therapy for refractory angina is limited and the prognosis is poor. Experimental data suggest that the use of extracorporeal shockwave myocardial revascularization (ESMR) can contribute to angiogenesis and improve symptoms of angina and left ventricular (LV) function. The objective of this study was to examine the effects of ESMR on clinical symptoms as well as LV function as assessed by cardiac MRI in...

read more